Chronic liver disease is triggered by taurine transporter knockout in the mouse.

doi:10.1096/fj.05-5016fje

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Chronic liver disease is triggered by taurine transporter knockout in the mouse.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2006

Warskulat Ulrich, Borsch Elena, Reinehr Roland, Heller-Stilb Birgit, Mönnighoff Irmhild, Buchczyk Darius, Donner Markus, Flögel Ulrich, Kappert Günther, Soboll Sibylle, Beer Sandra, Pfeffer Klaus, Marschall Hanns-Ulrich, Gabrielsen Marcus, Amiry-Moghaddam Mahmood, Ottersen Ole Petter, Dienes Hans Peter, Häussinger Dieter

Abstract excerpt

Taurine is an abundant organic osmolyte with antioxidant and immunomodulatory properties. Its role in the pathogenesis of chronic liver disease is unknown. The liver phenotype was studied in taurine transporter knockout (taut-/-) mice. Hepatic taurine levels were ~21, 15 and 6 mumol/g liver wet weight in adult wild-type, heterozygous (taut+/-) and homozygous (taut-/-) mice, respectively. Immunoelectronmicroscopy...

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PMID: 16421246
DOI: 10.1096/fj.05-5016fje

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