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Article

Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice.

American journal of physiology. Gastrointestinal and liver physiology - 15 Feb 2014

King Adrienne L, Swain Telisha M, Mao Zhengkuan, Udoh Uduak S, Oliva Claudia R, Betancourt Angela M, Griguer Corrine E, Crowe David R, Lesort Mathieu, Bailey Shannon M

Abstract excerpt

Chronic ethanol consumption increases sensitivity of the mitochondrial permeability transition (MPT) pore induction in liver. Ca(2+) promotes MPT pore opening, and genetic ablation of cyclophilin D (CypD) increases the Ca(2+) threshold for the MPT. We used wild-type (WT) and CypD-null (CypD(-/-)) mice fed a control or an ethanol-containing diet to investigate the role of the MPT in ethanol-mediated liver injury....

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Identifiers

PMID: 24356880
DOI: 10.1152/ajpgi.00278.2013
PMCID: PMC3920122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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