Article
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation.
Proceedings of the National Academy of Sciences of the United States of America - 8 May 2001
Lu S C, Alvarez L, Huang Z Z, Chen L, An W, Corrales F J, Avila M A, Kanel G, Mato J M
Abstract excerpt
Liver-specific and nonliver-specific methionine adenosyltransferases (MATs) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (AdoMet), the principal biological methyl donor. Mature liver expresses MAT1A, whereas MAT2A is expressed in extrahepatic tissues and is induced during liver growth and dedifferentiation. To examine the influence of MAT1A on...
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