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Article

Adenovirus helper function activity of simian virus 40 T antigen mutants.

Virology - 1 Aug 1992

Heath C V, Fanning E, Cole C N

Abstract excerpt

The SV40 large T antigen provides a helper function that permits human adenovirus yields in monkey cells to approach those obtained in human cells. The carboxy-terminus of large T antigen is involved in providing this activity. The ability of a large number of SV40 mutants affecting T antigen to enhance the growth of adenovirus type 2 in the CV-1 line of African green monkey kidney cells was examined. Mutation of...

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Identifiers

PMID: 1641988
DOI: 10.1016/0042-6822(92)90601-k

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