A DNA replication-positive mutant of simian virus 40 that is defective for transformation and the production of infectious virions.

doi:10.1128/JVI.64.6.2912-2921.1990

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Article

A DNA replication-positive mutant of simian virus 40 that is defective for transformation and the production of infectious virions.

Journal of virology - 1 Jun 1990

Peden K W, Spence S L, Tack L C, Cartwright C A, Srinivasan A, Pipas J M

Abstract excerpt

Simian virus 40 (SV40) mutant 5002 carries base pair substitutions of C-5109----T and C-5082----T. These mutations lie in a region of the genome that encodes amino acids common to the large and small viral tumor antigens (T and t antigens, respectively) and result in amino acid substitutions of L...

Topics

Adenosine Triphosphatases
Animals
Antigens, Polyomavirus Transforming
Base Sequence
Cell Line
Cell Transformation, Neoplastic
Cells, Cultured
DNA Replication
DNA, Viral
Defective Viruses
Genes, Viral
Mice
Molecular Sequence Data
Mutation
Phosphopeptides

Source

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Identifiers

PMID: 2159552
DOI: 10.1128/JVI.64.6.2912-2921.1990
PMCID: PMC249475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2159552-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Plasmids

Simian virus 40

Viral Plaque Assay