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Article

Cell cycle progression in monkey cells expressing simian virus 40 small t antigen from adenovirus vectors.

Journal of virology - 1 Dec 1998

Howe A K, Gaillard S, Bennett J S, Rundell K

Abstract excerpt

The simian virus 40 small t antigen (small-t) is required for optimal viral replication and transformation, especially during the infection of nondividing cells, suggesting that the function of small-t is to promote cell cycle progression. The mechanism through which small-t promotes cell growth reflects, in part, its binding and inhibition of protein phosphatase 2A (PP2A). The use of recombinant adenoviruses...

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Identifiers

PMID: 9811697
DOI: 10.1128/JVI.72.12.9637-9644.1998
PMCID: PMC110473

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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