Article
Interaction of simian virus 40 large T-antigen with cellular DNA polymerase alpha: studies with various T-antigen mutants of SV40.
Archives of virology - 1 Jan 1991
Pistillo J M, Vishwanatha J K
Abstract excerpt
Simian virus 40 (SV40) large T antigen binds to host cell DNA polymerase alpha and the T-antigen-DNA polymerase alpha complex is implicated in the initiation of viral DNA replication. We have examined various SV40 T-antigen mutants to test the correspondence between viral DNA replication and T-an...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Polyomavirus Transforming
- Cell Line
- DNA Polymerase II
- DNA Replication
- DNA, Viral
- Mutation
- Protein Binding
- Radioimmunoassay
- Simian virus 40
- Transfection