Article
Simian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products.
Molecular and cellular biology - 1 Apr 1991
Yaciuk P, Carter M C, Pipas J M, Moran E
Abstract excerpt
In this report we present evidence that simian virus 40 T antigen encodes a biological activity that is functionally equivalent to the transforming activity lost by deletion of the E1A p300-binding region. T-antigen constructs from which the pRb-binding region has been deleted are virtually unabl...
Topics
- Adenovirus Early Proteins
- Animals
- Antigens, Polyomavirus Transforming
- Cell Line
- Cell Transformation, Viral
- Cloning, Molecular
- Gene Expression
- Genetic Complementation Test
- Mutation
- Oncogene Proteins, Viral
- Precipitin Tests