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Article

Simian virus 40 small-t antigen stimulates viral DNA replication in permissive monkey cells.

Journal of virology - 1 May 1994

Cicala C, Avantaggiati M L, Graessmann A, Rundell K, Levine A S, Carbone M

Abstract excerpt

The simian virus 40 (SV40) large-T antigen is essential for SV40 DNA replication and for late viral gene expression, but the role of the SV40 small-t antigen in these processes is still unclear. We have previously demonstrated that small t inhibits SV40 DNA replication in vitro. In this study, we investigated the effect of small t on SV40 replication in cultured cells. CV1 monkey cell infection experiments...

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Identifiers

PMID: 8151779
DOI: 10.1128/JVI.68.5.3138-3144.1994
PMCID: PMC236804

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