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Article

CCR5 deficiency increases risk of symptomatic West Nile virus infection.

The Journal of experimental medicine - 23 Jan 2006

Glass William G, McDermott David H, Lim Jean K, Lekhong Sudkamon, Yu Shuk Fong, Frank William A, Pape John, Cheshier Ronald C, Murphy Philip M

Abstract excerpt

West Nile virus (WNV) is a reemerging pathogen that causes fatal encephalitis in several species, including mouse and human. Recently, we showed that the chemokine receptor CCR5 is critical for survival of mice infected with WNV, acting at the level of leukocyte trafficking to the brain. To test whether this receptor is also protective in man, we determined the frequency of CCR5Delta32, a defective CCR5 allele...

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Share to CCR5 gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16418398
DOI: 10.1084/jem.20051970
PMCID: PMC2118086

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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