Article
Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jan 2006
Tricarico Domenico, Mele Antonietta, Lundquist Andrew L, Desai Reshma R, George Alfred L, Conte Camerino Diana
Abstract excerpt
ATP-sensitive K(+) channels (K(ATP)) are an octameric complex of inwardly rectifying K(+) channels (Kir6.1 and Kir6.2) and sulfonylurea receptors (SUR1 and SUR2A/B), which are involved in several diseases. The tissue-selective expression of the subunits leads to different channels; however, the composition and role of the functional channel in native muscle fibers is not known. In this article, the properties of...
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