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Article

The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells.

Journal of molecular endocrinology - 1 Apr 1999

Miki T, Nagashima K, Seino S

Abstract excerpt

ATP-sensitive K+ channels (KATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. The KATP channels in pancreatic beta-cells are thought to be critical in the regulation of glucose-induced and sulfonylurea-induced insulin secretion. Until recently, however, the molecular structure of the KATP channel was not known. Cloning members of the novel inwardly...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10194514
DOI: 10.1677/jme.0.0220113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells.PMID 10194514Read ↗

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Molecular biology of K(ATP) channels and implications for health and disease.Semantic proximity Read ↗

Physiological and pathophysiological roles of ATP-sensitive K+ channels.Semantic proximity Read ↗

Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice.Semantic proximity Read ↗

Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism.Semantic proximity Read ↗

Sulfonylurea receptor -1 (SUR1): genetic and metabolic evidences for a role in the susceptibility to type 2 diabetes mellitus.Semantic proximity Read ↗

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Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism.Semantic proximity Read ↗

Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.Semantic proximity Read ↗

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