Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth.

Journal of molecular medicine (Berlin, Germany) - 1 Feb 2006

Flavell David M, Wootton Peter T E, Myerson Saul G, World Michael J, Pennell Dudley J, Humphries Steve E, Talmud Philippa J, Montgomery Hugh E

Abstract excerpt

The adult heart relies predominantly on fatty acids (FA) for energy generation, and defects in FA catabolism cause dramatic left ventricular (LV) growth in early age. Since lipoprotein lipase (LPL) is the key enzyme in plasma triglyceride catabolism and is highly expressed in the myocardium, we investigated an association between the functional LPL gene serine 447 stop (S447X) variant and exercise-induced LV...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Exercise

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Heart Ventricles

Share to Lipoprotein Lipase

Share to Losartan

Share to Military Personnel

Share to Reference Values

Source

Identifiers

PMID: 16416313
DOI: 10.1007/s00109-005-0002-8

Genes

LPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth.PMID 16416313Read ↗

The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease.Semantic proximity Read ↗

Peroxisome Proliferator–Activated Receptor α Gene Regulates Left Ventricular Growth in Response to Exercise and HypertensionSemantic proximity Read ↗

Exercise training-induced blood pressure and plasma lipid improvements in hypertensives may be genotype dependent.Semantic proximity Read ↗

Lipoprotein-associated phospholipase A2 A379V variant is associated with body composition changes in response to exercise training.Semantic proximity Read ↗

Hepatic lipase gene -514C>T variant is associated with exercise training-induced changes in VLDL and HDL by lipoprotein lipase.Semantic proximity Read ↗

Analysis of gene-environment interactions by "stressing-the-genotype" studies: the angiotensin converting enzyme and exercise-induced left ventricular hypertrophy as an example.Semantic proximity Read ↗

Left ventricular hypertrophy with exercise and ACE gene insertion/deletion polymorphism: a randomized controlled trial with losartan.Semantic proximity Read ↗

The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease.Semantic proximity Read ↗

C-reactive protein gene variant and the human left ventricular growth response to exercise: data from The LARGE Heart Study.Semantic proximity Read ↗

Blunted beta-adrenoceptor-mediated fat oxidation in overweight subjects: a role for the hormone-sensitive lipase gene.Semantic proximity Read ↗

The Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Modifies Exercise-Induced Muscle Metabolism.Semantic proximity Read ↗

The single nucleotide polymorphism Gly482Ser in the PGC-1α gene impairs exercise-induced slow-twitch muscle fibre transformation in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.