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Article

The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease.

Clinical science (London, England : 1979) - 1 Jun 2007

Talmud Philippa J, Flavell David M, Alfakih Khaled, Cooper Jackie A, Balmforth Anthony J, Sivananthan Mohan, Montgomery Hugh E, Hall Alistair S, Humphries Steve E

Abstract excerpt

LVH [LV (left ventricular) hypertrophy] is an independent risk factor for CHD (coronary heart disease). During LVH, the preferred cardiac energy substrate switches from FAs (fatty acids) to glucose. LPL (lipoprotein lipase) is the key enzyme in triacylglycerol (triglyceride) hydrolysis and supplies FAs to the heart. To investigate whether substrate utilization influences cardiac growth and CHD risk, we examined...

Read the complete abstract on PubMed

Topics

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Share to Apolipoproteins
Share to Coronary Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Acids

Share to Hypertrophy, Left Ventricular

Share to Lipoprotein Lipase

Share to Myocardium

Share to Serine

Share to Triglycerides

Source

Identifiers

PMID: 17291198
DOI: 10.1042/CS20060344

Genes

LPL

Variants

rs328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The lipoprotein lipase gene serine 447 stop variant influences hypertension-induced left ventricular hypertrophy and risk of coronary heart disease.PMID 17291198Read ↗

Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth.Semantic proximity Read ↗

Preheparin serum lipoprotein lipase mass interacts with gender, gene polymorphism and, positively, with smoking.Semantic proximity Read ↗

Effect of gender on phenotypic expression of the S447X mutation in LPL: the Copenhagen City Heart Study.Semantic proximity Read ↗

S447X variant of the lipoprotein lipase gene, lipids, and risk of coronary heart disease in 3 prospective cohort studies.Semantic proximity Read ↗

Complete Rescue of Lipoprotein Lipase–Deficient Mice by Somatic Gene Transfer of the Naturally Occurring LPLS447XBeneficial MutationSemantic proximity Read ↗

Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation.Semantic proximity Read ↗

The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease.Semantic proximity Read ↗

[The association of S447X and Hind III polymorphism in the lipoprotein lipase gene with dyslipidemia of the metabolic syndrome in patients with essential hypertension].Semantic proximity Read ↗

Association of the lipoprotein lipase gene Ser447Ter polymorphism with hypertension and blood pressure variation: evidence from an updated meta-analysis.Semantic proximity Read ↗

Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis.Semantic proximity Read ↗

A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study.Semantic proximity Read ↗

The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks.Semantic proximity Read ↗

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