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Article

The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease.

Clinical genetics - 1 Oct 2001

Clee S M, Loubser O, Collins J, Kastelein J J, Hayden M R

Abstract excerpt

Linkage of the lipoprotein lipase (LPL) gene to blood pressure levels has been reported. The LPL S447X single nucleotide polymorphism (cSNP) has been associated with decreased triglycerides (TG), increased high density lipoprotein cholesterol, and a decreased risk of coronary artery disease (CAD), which may occur independently of its beneficial lipid changes. To investigate the relationship between LPL S447X cSNP...

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Source

Identifiers

PMID: 11683775
DOI: 10.1034/j.1399-0004.2001.600407.x

Genes

LPL
CAD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The LPL S447X cSNP is associated with decreased blood pressure and plasma triglycerides, and reduced risk of coronary artery disease.PMID 11683775Read ↗

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The S447X variant of lipoprotein lipase gene is associated with metabolic syndrome and lipid levels among Turks.Semantic proximity Read ↗

A common truncation variant of lipoprotein lipase (Ser447X) confers protection against coronary heart disease: the Framingham Offspring Study.Semantic proximity Read ↗

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