Peroxisome Proliferator–Activated Receptor α Gene Regulates Left Ventricular Growth in Response to Exercise and Hypertension

Abstract excerpt

BACKGROUND: Left ventricular hypertrophy (LVH) occurs as an adaptive response to a physiological (such as exercise) or pathological (valvular disease, hypertension, or obesity) increase in cardiac work. The molecular mechanisms regulating the LVH response are poorly understood. However, inherited defects in fatty acid oxidation are known to cause severe early-onset cardiac hypertrophy. Peroxisome...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiovascular Effects of Exercise
• Share to Cardiovascular Function and Risk Factors
• Share to Peroxisome Proliferator-Activated Receptors