Analysis of gene-environment interactions by "stressing-the-genotype" studies: the angiotensin converting enzyme and exercise-induced left ventricular hypertrophy as an example.

Abstract excerpt

The human angiotensin converting enzyme (ACE) gene contains a length polymorphism consisting of the presence (insertion, I) or absence (deletion, D) of a 287 base pair "Alu" repeat sequence in intron 16, with the D allele being associated with higher ACE levels than the I allele in plasma and in tissues. We have carried out several studies to examine the relationship between this polymorphism and cardiovascular...

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