Hepatic lipase gene -514C>T variant is associated with exercise training-induced changes in VLDL and HDL by lipoprotein lipase.

doi:10.1152/japplphysiol.00567.2011

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Article

Hepatic lipase gene -514C>T variant is associated with exercise training-induced changes in VLDL and HDL by lipoprotein lipase.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Dec 2011

Brinkley Tina E, Halverstadt Amy, Phares Dana A, Ferrell Robert E, Prigeon Ronald L, Hagberg James M, Goldberg Andrew P

Abstract excerpt

Our objective was to test the hypothesis that a common polymorphism in the hepatic lipase (HL) gene (LIPC -514C>T, rs1800588) influences aerobic exercise training-induced changes in TG, very-low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) through genotype-specific increases in lipoprotein lipase (LPL) activity and that sex may affect these responses. Seventy-six sedentary overweight to obese...

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Identifiers

PMID: 21960661
DOI: 10.1152/japplphysiol.00567.2011
PMCID: PMC3233892

Genes

LPL
LIPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hepatic lipase gene -514C>T variant is associated with exercise training-induced changes in VLDL and HDL by lipoprotein lipase.PMID 21960661Read ↗

High-density lipoprotein-cholesterol, its subfractions, and responses to exercise training are dependent on endothelial lipase genotype.Semantic proximity Read ↗

Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study.Semantic proximity Read ↗

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The -514 C->T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis.Semantic proximity Read ↗

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Dietary Fat Intake Modifies the Effect of a Common Variant in the LIPC Gene on Changes in Serum Lipid Concentrations during a Long-Term Weight-Loss Intervention Trial.Semantic proximity Read ↗

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Dietary fat interacts with the -514C>T polymorphism in the hepatic lipase gene promoter on plasma lipid profiles in a multiethnic Asian population: the 1998 Singapore National Health Survey.Semantic proximity Read ↗

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