Article
mtDNA mutations in invasive cervix tumors: a retrospective analysis.
Cancer letters - 18 Nov 2006
Allalunis-Turner Joan, Ma Ivy, Hanson John, Pearcey Robert G
Abstract excerpt
We tested whether mtDNA mutations are associated with poor outcome in patients with invasive cervix cancer. Tumor samples were banked more than 10 years ago from women with diagnoses of invasive cervix cancer. Automated techniques were used to determine the sequence of the mtDNA-encoded Complex I subunits. Approximately one-third of all tumors had multiple mtDNA sequence alterations. Both univariate and...
Topics
- Adult
- DNA Mutational Analysis
- DNA, Mitochondrial
- Electron Transport Complex I
- Female
- Humans
- Middle Aged
- Multivariate Analysis
- Mutation
- Neoplasm Invasiveness
- Prognosis
- Retrospective Studies