Article
Mitochondrial genotype in vulvar carcinoma - cuckoo in the nest.
Journal of biomedical science - 8 Sept 2010
Klemba Aleksandra, Kowalewska Magdalena, Kukwa Wojciech, Tonska Katarzyna, Szybinska Aleksandra, Mossakowska Malgorzata, Scinska Anna, Golik Paweł, Koper Kamil, Radziszewski Jakub, Kukwa Andrzej, Czarnecka Anna M, Bartnik Ewa
Abstract excerpt
Vulvar squamous cell carcinoma (VSCC) is a rare female genital neoplasm. Although numerous molecular changes have been reported in VSCC, biomarkers of clinical relevance are still lacking. On the other hand, there is emerging evidence on the use of mtDNA as a diagnostic tool in oncology. In order to investigate mtDNA status in VSCC patients, haplogroup distribution analysis and D-loop sequencing were performed....
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