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Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women.

Cancer research - 1 Sept 2005

Canter Jeffrey A, Kallianpur Asha R, Parl Fritz F, Millikan Robert C

Abstract excerpt

Mitochondria generate oxygen-derived free radicals that damage mitochondrial DNA (mtDNA) as well as nuclear DNA and in turn promote carcinogenesis. The mtDNA G10398A polymorphism alters the structure of Complex I in the mitochondrial electron transport chain, an important site of free radical production. This polymorphism is associated with several neurodegenerative disorders. We hypothesized that the 10398A...

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Source

Identifiers

PMID: 16140977
DOI: 10.1158/0008-5472.CAN-05-1428

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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