Article
Evaluation of Aurora-A gene polymorphism and esophageal cancer risk in a South Indian population.
Genetic testing and molecular biomarkers - 1 Mar 2011
Chava Srinivas, Mohan Vasavi, Pasupuleti Nagarjuna, Latha Manolla Madhavi, Khan Imran Ali, Upendram Pavani, Kumar Ajith, Ahuja Yog R, Hasan Qurratulain
Abstract excerpt
AIM: Aurora-A is a serine/threonine protein kinase that functions in centrosome maturation and spindle assembly and is involved in regulating chromosome segregation. It is amplified and overexpressed in several human cancers. The aim of the present study was to assess the role of T91A Aurora-A gene polymorphism associated with aneuploidy in human tumors. RESULT: Patients with different upper gastrointestinal...
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