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Article

The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.

Development (Cambridge, England) - 1 Oct 2005

Kiernan Amy E, Cordes Ralf, Kopan Raphael, Gossler Achim, Gridley Thomas

Abstract excerpt

The mammalian auditory sensory epithelium, the organ of Corti, contains sensory hair cells and nonsensory supporting cells arranged in a highly patterned mosaic. Notch-mediated lateral inhibition is the proposed mechanism for creating this sensory mosaic. Previous work has shown that mice lacking the Notch ligand JAG2 differentiate supernumerary hair cells in the cochlea, consistent with the lateral inhibitory...

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Share to Calcium-Binding Proteins
Share to Ear, Inner

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Hair Cells, Auditory

Share to Intercellular Signaling Peptides and Proteins

Share to Organ of Corti

Share to Receptor, Notch1

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Source

Identifiers

PMID: 16141228
DOI: 10.1242/dev.02002

Genes

JAG2
DLL1
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.PMID 16141228Read ↗

Notch signalling pathway mediates hair cell development in mammalian cochlea.Semantic proximity Read ↗

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Neurod1 suppresses hair cell differentiation in ear ganglia and regulates hair cell subtype development in the cochlea.Semantic proximity Read ↗

Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle earSemantic proximity Read ↗

Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.Semantic proximity Read ↗

foxg1a is required for hair cell development and regeneration in the zebrafish lateral line.Semantic proximity Read ↗

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