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Article

Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition.

Molecular cell - 22 Dec 2005

Yang Jin Kuk, Wang Liwei, Zheng Lixin, Wan Fengyi, Ahmed Misonara, Lenardo Michael J, Wu Hao

Abstract excerpt

The death-inducing signaling complex (DISC) comprising Fas, Fas-associated death domain (FADD), and caspase-8/10 is assembled via homotypic associations between death domains (DDs) of Fas and FADD and between death effector domains (DEDs) of FADD and caspase-8/10. Caspase-8/10 and FLICE/caspase-8 inhibitory proteins (FLIPs) that inhibit caspase activation at the DISC level contain tandem DEDs. Here, we report the...

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Identifiers

PMID: 16364918
DOI: 10.1016/j.molcel.2005.10.023
PMCID: PMC2908330

Genes

FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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