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Article

FADD self-association is required for stable interaction with an activated death receptor.

Cell death and differentiation - 1 Dec 2006

Sandu C, Morisawa G, Wegorzewska I, Huang T, Arechiga A F, Hill J M, Kim T, Walsh C M, Werner M H

Abstract excerpt

Receptor-mediated programmed cell death proceeds through an activated receptor to which the death adaptor FADD and the initiator procaspases 8 and/or 10 are recruited following receptor stimulation. The adaptor FADD is responsible for both receptor binding and recruitment of the procaspases into the death-inducing signaling complex. Biochemical dissection of the FADD death effector domain and functional...

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Source

Identifiers

PMID: 16710361
DOI: 10.1038/sj.cdd.4401966

Genes

FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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