Article
Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD.
The Journal of biological chemistry - 30 Jul 2004
Thomas Lance R, Henson Adrianna, Reed John C, Salsbury Freddie R, Thorburn Andrew
Abstract excerpt
Members of the tumor necrosis factor superfamily of receptors induce apoptosis by recruiting adaptor molecules through death domain interactions. The central adaptor molecule for these receptors is the death domain-containing protein Fas-associated death domain (FADD). FADD binds a death domain on a receptor or additional adaptor and recruits caspases to the activated receptor. Tumor necrosis factor-related...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Apoptosis
- Carrier Proteins
- Caspases
- Cell Line
- Cloning, Molecular
- Co-Repressor Proteins
- Enzyme Activation
- Green Fluorescent Proteins