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Article

A mechanism for death receptor discrimination by death adaptors.

The Journal of biological chemistry - 9 Sept 2005

Sandu Cristinel, Gavathiotis Evripidis, Huang Ted, Wegorzewska Iga, Werner Milton H

Abstract excerpt

The death domain and death effector domain are two common motifs that mediate protein-protein interactions between components of cell death signaling complexes. The mechanism by which these domains engage their binding partners has been explored by extensive mutagenesis of two death adaptors, FADD and TRADD, suggesting that a death adaptor can discriminate its intended binding partners from other proteins...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16006552
DOI: 10.1074/jbc.M506938200

Genes

FADD
TRADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mechanism for death receptor discrimination by death adaptors.PMID 16006552Read ↗

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