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Controlling Cell Death through Post-translational Modifications of DED Proteins

29 Mar 2020

Abstract excerpt

Death-inducing signaling complex (DISC) and death effector domain (DED) filaments control extrinsic apoptosis.DED filaments comprise FADD, procaspase-8/10, and c-FLIP.Post-translational modifications (PTMs) of DED filament proteins create the additional checkpoint of apoptosis.A central role in understanding apoptosis control is in deciphering the 3D architecture of PTMs in the DED filament. Apoptosis is a form...

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PMID: 32302548
DOI: 10.1016/j.tcb.2020.02.006

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