Fyn is required for haloperidol-induced catalepsy in mice.

doi:10.1074/jbc.M511608200

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Article

Fyn is required for haloperidol-induced catalepsy in mice.

The Journal of biological chemistry - 17 Mar 2006

Hattori Kotaro, Uchino Shigeo, Isosaka Tomoko, Maekawa Mamiko, Iyo Masaomi, Sato Toshio, Kohsaka Shinichi, Yagi Takeshi, Yuasa Shigeki

Abstract excerpt

Fyn-mediated tyrosine phosphorylation of N-methyl-D-aspartate (NMDA) receptor subunits has been implicated in various brain functions, including ethanol tolerance, learning, and seizure susceptibility. In this study, we explored the role of Fyn in haloperidol-induced catalepsy, an animal model of the extrapyramidal side effects of antipsychotics. Haloperidol induced catalepsy and muscle rigidity in the control...

Topics

Animals
Anti-Dyskinesia Agents
Antipsychotic Agents
Blotting, Western
Calcium
Catalepsy
Cells, Cultured
Dopamine
Genotype
Haloperidol
Immunoblotting
Immunohistochemistry
Immunoprecipitation
In Situ Hybridization

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Indoles

Mice

Neurons

Phosphorylation

Source

Open in PubMed

Identifiers

PMID: 16407246
DOI: 10.1074/jbc.M511608200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.