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Article

Resistance to alcohol withdrawal-induced behaviour in Fyn transgenic mice and its reversal by ifenprodil.

Brain research. Molecular brain research - 30 Sept 2002

Stork Oliver, Kojima Nobuhiko, Stork Simone, Kume Nobuko, Obata Kunihiko

Abstract excerpt

Recent studies suggest that the protein tyrosine kinase Fyn constitutes a determinant of fear and anxiety as well as alcohol sensitivity in mice. We investigated these functions and their relatedness in mice with transgenic over-expression of native or mutated, constitutively active Fyn. Fear- and anxiety-related behaviour of these animals were normal under varying levels of stress, but under withdrawal from...

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Identifiers

PMID: 12399115
DOI: 10.1016/s0169-328x(02)00400-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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