Article
Regional localization of Fyn in adult brain; studies with mice in which fyn gene was replaced by lacZ.
Oncogene - 1 Dec 1993
Yagi T, Shigetani Y, Okado N, Tokunaga T, Ikawa Y, Aizawa S
Abstract excerpt
Mutant mice in which beta-galactosidase gene (lacZ) was inserted into fyn locus were generated by homologous recombination in embryonic stem cells to examine the Fyn expression in the central nervous system. In adult brain, intensive beta-galactosidase activity was observed in olfactory bulb, cerebellum and hippocampus of the limbic system; the subcellular distribution of the activity was apparent not only in...
Topics
- Animals
- Base Sequence
- Blotting, Western
- Brain Chemistry
- Cerebellum
- Cerebral Cortex
- Embryo, Mammalian
- Gene Expression
- Heterozygote
- Hippocampus
- Homozygote
- In Situ Hybridization, Fluorescence