Article
Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors.
Neurobiology of disease - 1 Dec 2005
Woldbye David P D, Nanobashvili Avtandil, Sørensen Andreas T, Husum Henriette, Bolwig Tom G, Sørensen Gunnar, Ernfors Patrik, Kokaia Merab
Abstract excerpt
Neuropeptide Y (NPY) prominently inhibits epileptic seizures in different animal models. The NPY receptors mediating this effect remain controversial partially due to lack of highly selective agonists and antagonists. To circumvent this problem, we used various NPY receptor knockout mice with the same genetic background and explored anti-epileptic action of NPY in vitro and in vivo. In Y2 (Y2-/-) and Y5 (Y5-/-)...
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