Article
Docosahexaenoic acid reduces haloperidol-induced dyskinesias in mice: involvement of Nur77 and retinoid receptors.
Biological psychiatry - 1 Oct 2004
Ethier Isabelle, Kagechika Hiroyuki, Shudo Koichi, Rouillard Claude, Lévesque Daniel
Abstract excerpt
BACKGROUND: Treatment of schizophrenia's symptoms with typical antipsychotic drugs shows some efficacy, but the induction of extrapyramidal symptoms represents a serious handicap, which considerably limits their usefulness. Recent evidence suggests that Nur77 (nerve growth factor-induced B) and retinoids are involved in biochemical and behavioral effects of antipsychotic drugs associated with striatal functions....
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