Article
Increased expression of the chemokine fractalkine in Crohn's disease and association of the fractalkine receptor T280M polymorphism with a fibrostenosing disease Phenotype.
The American journal of gastroenterology - 1 Jan 2006
Brand Stephan, Hofbauer Katrin, Dambacher Julia, Schnitzler Fabian, Staudinger Tanja, Pfennig Simone, Seiderer Julia, Tillack Cornelia, Konrad Astrid, Göke Burkhard, Ochsenkühn Thomas, Lohse Peter
Abstract excerpt
BACKGROUND: The fractalkine receptor CX3CR1 has been shown to be involved in inflammation and immune response. Recently, two polymorphisms of CX3CR1 (V249I and T280M) were reported. AIMS: Our aim was to analyze fractalkine expression and the role of CX3CR1 polymorphisms in Crohn's disease (CD). METHODS: We determined fractalkine mRNA expression in the intestinal epithelial cell (IEC) line SW480 after stimulation...
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