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Article

The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection.

Journal of hepatology - 1 Feb 2008

Wasmuth Hermann E, Zaldivar Mirko Moreno, Berres Marie-Luise, Werth Alexa, Scholten David, Hillebrandt Sonja, Tacke Frank, Schmitz Petra, Dahl Edgar, Wiederholt Tonio, Hellerbrand Claus, Berg Thomas, Weiskirchen Ralf, Trautwein Christian, Lammert Frank

Abstract excerpt

BACKGROUND/AIMS: The chemokine receptor CX3CR1 and its specific ligand fractalkine (CX3CL1) are known to modulate inflammatory and fibroproliferative diseases. Here we investigate the role of CX3CR1/fractalkine in HCV-induced liver fibrosis. METHODS: A genotype analysis of CX3CR1 variants was performed in 211 HCV-infected patients. Hepatic expression of CX3CR1 was studied in HCV-infected livers and isolated liver...

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Share to CX3C Chemokine Receptor 1
Share to Hepatitis C, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Cirrhosis

Share to Polymorphism, Single Nucleotide

Share to Receptors, Chemokine

Share to RNA, Messenger

Share to Tissue Inhibitor of Metalloproteinase-1

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Identifiers

PMID: 18078680
DOI: 10.1016/j.jhep.2007.09.008

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