Article
Opposite effects of CX3CR1 receptor polymorphisms V249I and T280M on the development of acute coronary syndrome. A possible implication of fractalkine in inflammatory activation.
Thrombosis and haemostasis - 1 May 2005
Niessner Alexander, Marculescu Rodrig, Haschemi Arvand, Endler Georg, Zorn Gerlinde, Weyand Cornelia M, Maurer Gerald, Mannhalter Christine, Wojta Johann, Wagner Oswald, Huber Kurt
Abstract excerpt
Several lines of evidence suggest that the chemokine fractalkine (FKN) and its receptor CX3CR1 contribute to the accumulation of leukocytes in the atherosclerotic plaque. The M280 allele of the CX3CR1T280M polymorphism modulates leukocyte recruitment and is associated with lower prevalence of cardiovascular disease. The influence of V249I, another CX3CR1 polymorphism, is discussed controversially. We investigated...
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