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Article

The V249I polymorphism of the CX3CR1 gene is associated with fibrostenotic disease behavior in patients with Crohn's disease.

European journal of gastroenterology & hepatology - 1 Aug 2008

Sabate Jean-Marc, Ameziane Nejma, Lamoril Jérôme, Jouet Pauline, Farmachidi Jean-Pierre, Soulé Jean-Claude, Harnois Florence, Sobhani Iradj, Jian Raymond, Deybach Jean-Charles, de Prost Dominique, Coffin Benoit

Abstract excerpt

OBJECTIVES: CX3CR1, the receptor of CX3CL1/fractalkine, is involved in regulation of inflammatory response and the CX3CR1-I249-M280 naturally occurring mutants are associated with altered binding to the ligand. Our aim was to evaluate the frequency of CX3CR1 V249I and T280M polymorphisms and NOD2/CARD15 mutations in Crohn's disease patients and to search for a relationship with phenotype. METHODS: Clinical data...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18617779
DOI: 10.1097/MEG.0b013e3282f824c9

Genes

NOD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The V249I polymorphism of the CX3CR1 gene is associated with fibrostenotic disease behavior in patients with Crohn's disease.PMID 18617779Read ↗

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