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Article

Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.

Nature immunology - 1 Nov 2004

Unniraman Shyam, Zhou Shaoming, Schatz David G

Abstract excerpt

Chromosomal translocations involving immunoglobulin heavy chain (Igh) switch regions and an oncogene such as Myc represent initiating events in the development of many B cell malignancies. These translocations are widely thought to result from aberrant class-switch recombination. To test this model, we measured translocations in mice deficient in activation-induced cytidine deaminase (AID) that lack class-switch...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15489857
DOI: 10.1038/ni1127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of an AID-independent pathway for chromosomal translocations between the Igh switch region and Myc.PMID 15489857Read ↗

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AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH TranslocationsSemantic proximity Read ↗

A role for AID in chromosome translocations between c-myc and the IgH variable regionSemantic proximity Read ↗

The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.Semantic proximity Read ↗

The Double-Edged Sword of Activation-Induced Cytidine DeaminaseSemantic proximity Read ↗

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