Article
Mutation scanning of the RET protooncogene using high-resolution melting analysis.
Clinical chemistry - 1 Jan 2006
Margraf Rebecca L, Mao Rong, Highsmith W Edward, Holtegaard Leonard M, Wittwer Carl T
Abstract excerpt
BACKGROUND: Single-base pair missense mutations in exons 10, 11, 13, 14, 15, and 16 of the RET protooncogene are associated with the autosomal dominant multiple endocrine neoplasia type 2 (MEN2) syndromes: MEN2A, MEN2B, and familial medullary thyroid carcinoma. The current widely used approach for RET mutation detection is sequencing of the exons. METHODS: Because RET mutations are rare and the majority are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.