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Article

Rapid diagnosis of MEN2B using unlabeled probe melting analysis and the LightCycler 480 instrument.

The Journal of molecular diagnostics : JMD - 1 Mar 2008

Margraf Rebecca L, Mao Rong, Wittwer Carl T

Abstract excerpt

Multiple endocrine neoplasia type 2B (MEN2B) is an autosomal dominant, inherited cancer syndrome. MEN2B patients have a high risk of developing medullary thyroid carcinoma, and prophylactic thyroidectomy is recommended by 6 months of age. Genetic testing can identify MEN2B patients before cancer progression. Two RET proto-oncogene mutations, in exon 15 at codon 883 (GCT>TTT) and in exon 16 at codon 918 (ATG>ACG),...

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Identifiers

PMID: 18258924
DOI: 10.2353/jmoldx.2008.070111
PMCID: PMC2259465

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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