Article
A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma.
Cancer research - 15 Feb 1996
Righetti S C, Della Torre G, Pilotti S, Ménard S, Ottone F, Colnaghi M I, Pierotti M A, Lavarino C, Cornarotti M, Oriana S, Böhm S, Bresciani G L, Spatti G, Zunino F
Abstract excerpt
The p53 protein is a multifunctional transcriptional regulator involved in cellular response to DNA damage and has been implicated as a putative determinant of sensitivity of tumor cells to cytotoxic agents. Since the p53 gene becomes inactivated in over one-half of advanced ovarian carcinoma, in this study we have examined the relationships between p53 gene alterations, p53 immunoreactivity, and response to...
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