High incidence of p53 gene mutation in human ovarian cancer and its association with nuclear accumulation of p53 protein and tumor DNA aneuploidy.

doi:10.1111/j.1349-7006.1992.tb02010.x

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Article

High incidence of p53 gene mutation in human ovarian cancer and its association with nuclear accumulation of p53 protein and tumor DNA aneuploidy.

Japanese journal of cancer research : Gann - 1 Sept 1992

Kihana T, Tsuda H, Teshima S, Okada S, Matsuura S, Hirohashi S

Abstract excerpt

Using the polymerase chain reaction and single-strand conformation polymorphism analysis, p53 gene mutations were examined in 24 cases of ovarian tumor including 14 ovarian carcinomas and 2 borderline cases of common epithelial type, 7 germ cell tumors, and one stromal tumor. Abnormal bands indic...

Topics

Aneuploidy
Base Sequence
Cell Nucleus
Female
Flow Cytometry
Genes, p53
Humans
Immunohistochemistry
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Ovarian Neoplasms
Polymerase Chain Reaction
Sequence Analysis, DNA
Tumor Suppressor Protein p53

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Identifiers

PMID: 1429209
DOI: 10.1111/j.1349-7006.1992.tb02010.x
PMCID: PMC5918982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1429209-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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