Overexpression and mutation of p53 in epithelial ovarian cancer.

Article

Overexpression and mutation of p53 in epithelial ovarian cancer.

Cancer research - 1 Jun 1991

Marks J R, Davidoff A M, Kerns B J, Humphrey P A, Pence J C, Dodge R K, Clarke-Pearson D L, Iglehart J D, Bast R C, Berchuck A

Abstract excerpt

We examined p53 expression in 107 epithelial ovarian cancers with immunohistochemical techniques using monoclonal antibody PAb1801. High level expression of nuclear p53 protein was detected in the malignant epithelium in 54 (50%) of these cancers. Expression of p53 protein was undetectable in 13...

Topics

Amino Acid Sequence
DNA, Neoplasm
Female
Gene Amplification
Genes, p53
Humans
Molecular Sequence Data
Mutation
Neoplasm Staging
Ovarian Neoplasms
Ploidies

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