Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down-regulation of nucleosomal binding protein HMGN1 expression during embryogenesis modulates Sox9 expression in chondrocytes.

Molecular and cellular biology - 1 Jan 2006

Furusawa Takashi, Lim Jae-Hwan, Catez Frédéric, Birger Yehudit, Mackem Susan, Bustin Michael

Abstract excerpt

We find that during embryogenesis the expression of HMGN1, a nuclear protein that binds to nucleosomes and reduces the compaction of the chromatin fiber, is progressively down-regulated throughout the entire embryo, except in committed but continuously renewing cell types, such as the basal layer of the epithelium. In the developing limb bud, the expression of HMGN1 is complementary to Sox9, a master regulator of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chondrocytes
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Development

Share to High Mobility Group Proteins

Share to Limb Buds

Share to Nucleosomes

Share to SOX9 Transcription Factor

Share to Tissue Culture Techniques

Source

Open in PubMed Open full text

Identifiers

PMID: 16382150
DOI: 10.1128/MCB.26.2.592-604.2006
PMCID: PMC1346905

Genes

HMGN1
HMGN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-regulation of nucleosomal binding protein HMGN1 expression during embryogenesis modulates Sox9 expression in chondrocytes.PMID 16382150Read ↗

Chromosomal protein HMGN1 modulates the expression of N-cadherin.Semantic proximity Read ↗

The HMGN Proteins Are Transcriptional Regulatory Factors in HumansSemantic proximity Read ↗

HMG chromosomal proteins in development and disease.Semantic proximity Read ↗

Expression Patterns and Function of Chromatin Protein HMGB2 during Mesenchymal Stem Cell DifferentiationSemantic proximity Read ↗

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian ChondrocyteSemantic proximity Read ↗

Functional compensation among HMGN variants modulates the DNase I hypersensitive sites at enhancers.Semantic proximity Read ↗

Repression of chondrogenesis through binding of notch signaling proteins HES‐1 and HEY‐1 to N‐box domains in the COL2A1 enhancer siteSemantic proximity Read ↗

Evolutionarily conserved, growth plate zone-specific regulation of the matrilin-1 promoter: L-Sox5/Sox6 and Nfi factors bound near TATA finely tune activation by Sox9.Semantic proximity Read ↗

Sox9 is required for cartilage formation.Semantic proximity Read ↗

Variants in the SOX9 transactivation middle domain induce axial skeleton dysplasia and scoliosisSemantic proximity Read ↗

Transcriptional control of chondrocyte fate and differentiationSemantic proximity Read ↗

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.