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Repression of chondrogenesis through binding of notch signaling proteins HES‐1 and HEY‐1 to N‐box domains in the COL2A1 enhancer site

29 Aug 2008

Abstract excerpt

OBJECTIVE: Notch signaling is implicated in the repression of mesenchymal stem cell (MSC) chondrogenic differentiation. The purpose of this study was to examine the mechanism of this repression and how it is modulated to permit chondrogenesis. METHODS: Notch intracellular domain (NICD) protein levels were monitored via Western blotting throughout chondrogenic differentiation of human MSCs in pellet cultures....

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PMID: 18759300
DOI: 10.1002/art.23730

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