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Article

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.

Nature genetics - 1 Feb 2006

Koshiba-Takeuchi Kazuko, Takeuchi Jun K, Arruda Eric P, Kathiriya Irfan S, Mo Rong, Hui Chi-chung, Srivastava Deepak, Bruneau Benoit G

Abstract excerpt

Human mutations in TBX5, a gene encoding a T-box transcription factor, and SALL4, a gene encoding a zinc-finger transcription factor, cause similar upper limb and heart defects. Here we show that Tbx5 regulates Sall4 expression in the developing mouse forelimb and heart; mice heterozygous for a gene trap allele of Sall4 show limb and heart defects that model human disease. Tbx5 and Sall4 interact both positively...

Read the complete abstract on PubMed

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Share to Atrial Natriuretic Factor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 10

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Share to Limb Deformities, Congenital

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Source

Identifiers

PMID: 16380715
DOI: 10.1038/ng1707

Genes

SALL4
TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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