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Article

Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.

Journal of molecular and cellular cardiology - 1 Jan 2018

Ghosh Tushar K, Aparicio-Sánchez José J, Buxton Sarah, Ketley Ami, Mohamed Tasabeeh, Rutland Catrin S, Loughna Siobhan, Brook J David

Abstract excerpt

TBX5 plays a critical role in heart and forelimb development. Mutations in TBX5 cause Holt-Oram syndrome, an autosomal dominant condition that affects the formation of the heart and upper-limb. Several studies have provided significant insight into the role of TBX5 in cardiogenesis; however, how TBX5 activity is regulated by other factors is still unknown. Here we report that histone acetyltransferases KAT2A and...

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Source

Identifiers

PMID: 29174768
DOI: 10.1016/j.yjmcc.2017.11.013

Genes

TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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