Article
Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.
Developmental biology - 15 Sept 2006
Mori Alessandro D, Zhu Yonghong, Vahora Ilyas, Nieman Brian, Koshiba-Takeuchi Kazuko, Davidson Lorinda, Pizard Anne, Seidman J G, Seidman Christine E, Chen X Josette, Henkelman R Mark, Bruneau Benoit G
Abstract excerpt
Dominant mutations in the T-box transcription factor gene TBX5 cause Holt-Oram syndrome (HOS), an inherited human disease characterized by upper limb malformations and congenital heart defects (CHDs) of variable severity. We hypothesize that minor alterations in the dosage of Tbx5 directly influences severity of CHDs. Using a mouse allelic series, we show a sensitive inverse correlation between Tbx5 dosage and...
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