Article
The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10.
Development (Cambridge, England) - 1 Nov 2002
Ng Jennifer K, Kawakami Yasuhiko, Büscher Dirk, Raya Angel, Itoh Tohru, Koth Christopher M, Rodríguez Esteban Concepción, Rodríguez-León Joaquín, Garrity Deborah M, Fishman Mark C, Izpisúa Belmonte Juan Carlos
Abstract excerpt
A major gap in our knowledge of development is how the growth and identity of tissues and organs are linked during embryogenesis. The vertebrate limb is one of the best models to study these processes. Combining mutant analyses with gain- and loss-of-function approaches in zebrafish and chick embryos, we show that Tbx5, in addition to its role governing forelimb identity, is both necessary and sufficient for limb...
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