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Article

Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo.

Development (Cambridge, England) - 1 Feb 2003

Agarwal Pooja, Wylie John N, Galceran Juan, Arkhitko Oksana, Li Cuiling, Deng Chuxia, Grosschedl Rudolf, Bruneau Benoit G

Abstract excerpt

Transcriptional cascades responsible for initiating the formation of vertebrate embryonic structures such as limbs are not well established. Limb formation occurs as a result of interplay between fibroblast growth factor (FGF) and Wnt signaling. What initiates these signaling cascades and thus limb bud outgrowth at defined locations along the anteroposterior axis of the embryo is not known. The T-box...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12490567
DOI: 10.1242/dev.00191

Genes

TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo.PMID 12490567Read ↗

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